Backup Exec 2014 Disk Storage options

I have a Dell R610 1U server.  It has ESXi 5.5 on it.  Attached to that server via SAS cable is a Dell PowerVault device, 27TB

Right now I have a single Windows 2012 R2 VM on the ESXi host, that I plan on installing Backup Exec on to.  The attached storage is seen by the ESXi host as a single 27TB VMFS 5.0 volume.

My question is can I use a VMDK file attached to the Windows VM running Backup Exec as backup storage?  I would probably give it 10-20 TB vmdk, format it as GPT in the Windows VM, and use it as a de-duplication disk, if its supported.

Thanks for any input!